2004•Journal of the American Chemical SocietyRequires access

A Dimerization “Switch” in the Internalization Mechanism of a Cell-Penetrating Peptide

Jason A. Moss, Antonietta M. Lillo, Young Soo Kim, Changshou Gao, Henrik J. Ditzel, Kim D. Janda

Abstract

The internalization mechanism of a cell-penetrating peptide has been explored through combinatorial selection of a phage-displayed peptide dimer library, chemical synthesis, and biophysical characterization. Both energy-dependent and energy-independent modes for peptide uptake by the target mammalian cells were observed, suggesting a role for higher-order structure in modulating the action of this novel cell-penetrating peptide.

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Key concepts: Internalization, Chemistry, Peptide, Cell-penetrating peptide, Biophysics, Dimer, Mechanism of action, Mechanism (biology)