A Multicenter Study on the Use of Transdermal Clonidine in Patients with Essential Hypertension

Non-diuretic antihypertensive agents now are frequently used in the treatment of patients with mild essential hypertension (Campese 1980; Mroczek 1983). In these patients, blood pressure is often controlled using oral therapy with a single agent. Recently, a new delivery system for monotherapy with the centrally-acting sympatholytic agent clonidine has become available. In this study, we describe the results of a multicenter study using an adhesive skin device containing clonidine (Catapres-TTS). The results indicate that treatment with a transdermal delivery system for clonidine is effective and well tolerated in patients with mild hypertension. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.