1997•Food and Chemical ToxicologyRequires access

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

Hakam Hadidi, K. Zahlsen, Jeffrey R. Idle, S. Cholerton

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Key concepts: CYP2A6, Hydroxylation, Coumarin, Chemistry, Cytochrome P450, Monooxygenase, Biochemistry, Metabolism

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A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin — Research Paper | ScholarLens