1975•Journal of Pharmacy and PharmacologyRequires access

A simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in plasma by gas liquid chromatography

Michael J. Rance, B. J. Jordan, J. Doland Nichols

Abstract

A novel method for the simultaneous determination of acetylsalicylic acid, salicylic acid and salicylamide in biological fluids by gas liquid chromatography is described. The assay has been used to determine the plasma concentration of salicylates in 10 volunteers after oral ingestion of three commercially available aspirin-containing formulations. No difficulty was encountered in determining low concentrations of acetylsalicylic acid in the presence of higher concentrations of salicylic acid. The in vivo plasma half life of acetylsalicylic acid in man was found to be 15.5 min.

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Key concepts: Salicylamide, Salicylic acid, Chemistry, Chromatography, Aspirin, Gas chromatography, Ingestion, Organic chemistry