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Inhibition of Squalene Synthase but Not Squalene Cyclase Prevents Mevalonate-Mediated Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Synthesis at a Posttranscriptional Level

Dennis M. Peffley, Apurba K. Gayen

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Key concepts: Squalene, Coenzyme A, Reductase, ATP synthase, Chemistry, Farnesyl-diphosphate farnesyltransferase, Cyclase, Hydroxymethylglutaryl-CoA reductase

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Inhibition of Squalene Synthase but Not Squalene Cyclase Prevents Mevalonate-Mediated Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Synthesis at a Posttranscriptional Level — Research Paper | ScholarLens