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EFFECT OF NITROUS OXIDE ON THE ANAESTHETIC REQUIREMENT OF ENFLURANE

Giangiacomo Torri, Giovanna L.M. Damia, M. L. FABIANI

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Abstract

The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25–36 min in order to equilibrate the brain with the alveolar anaesthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used.

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What this paper is about

The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25–36 min in order to equilibrate the brain with the alveolar anaesthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used.

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Available abstract

The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25–36 min in order to equilibrate the brain with the alveolar anaesthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used.

Key concepts: Enflurane, Nitrous oxide, Anesthesia, Medicine, Minimum alveolar concentration, Halothane, Partial pressure, Oxygen

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