1996•Biomedical ChromatographyRequires access

Effect of temperature on the high-performance liquid chromatographic separation of the anti-HIV agents, didanosine and stavudine

Frank A. Stancato, Nuggehally R. Srinivas, Catherine A. Knupp

Abstract

This paper examines the effect of temperature on the chromatographic separation characteristics of anti-HIV agents, didanosine and stavudine. As a result of lowering the column temperature, an improved resolution between didanosine and stavudine peaks is observed. Thus, lower temperatures may permit the simultaneous monitoring of didanosine and stavudine levels.

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Key concepts: Stavudine, Didanosine, Chemistry, Chromatography, Chromatographic separation, Human immunodeficiency virus (HIV), Zidovudine, Virology