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2013•Critical CareOpen access

Lung elastance can be determined without esophageal pressure measurements

Christina Grivans, S. Lundin, Ola Stenqvist

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Abstract

We have previously shown, in an ex vivo porcine model, that lung elastance calculated as the PEEP change divided by lung volume increase (ΔPEEP/ΔEELV) is closely correlated to conventionally measured lung elastance using oesophageal pressure [ 1 ]. In this study we hypothesize that the successive change in lung volume during a PEEP-step manoeuvre could be predicted from ΔPEEP and lung elastance as ΔPEEP/EL. The objective of the study was to validate this hypothesis in patients with acute respiratory failure (ARF).

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What this paper is about

We have previously shown, in an ex vivo porcine model, that lung elastance calculated as the PEEP change divided by lung volume increase (ΔPEEP/ΔEELV) is closely correlated to conventionally measured lung elastance using oesophageal pressure [ 1 ]. In this study we hypothesize that the successive change in lung volume during a PEEP-step manoeuvre could be predicted from ΔPEEP and lung elastance as ΔPEEP/EL. The objective of the study was to validate this hypothesis in patients with acute respiratory failure (ARF).

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Available abstract

We have previously shown, in an ex vivo porcine model, that lung elastance calculated as the PEEP change divided by lung volume increase (ΔPEEP/ΔEELV) is closely correlated to conventionally measured lung elastance using oesophageal pressure [ 1 ]. In this study we hypothesize that the successive change in lung volume during a PEEP-step manoeuvre could be predicted from ΔPEEP and lung elastance as ΔPEEP/EL. The objective of the study was to validate this hypothesis in patients with acute respiratory failure (ARF).

Key concepts: Elastance, Medicine, Lung, Lung volumes, Acute respiratory failure, Positive end-expiratory pressure, Respiratory physiology, Respiratory system

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