2012•OncoImmunologyOpen access

Inhibition of CXCLs/CXCR2 axis in the tumor microenvironment might be a potent therapeutics for pancreatic cancer

Hideaki Ijichi

Abstract

Pancreatic cancer is characterized by expanded stroma with marked fibrosis. In Ijichi et al., we show that inhibiting CXCR2 disrupts tumor-stromal interactions and improves survival of a genetically-engineered mouse model recapitulating human pancreatic cancer. Targeting CXCLs/CXCR2 axis in the tumor microenvironment might be a potent therapeutic strategy for pancreatic cancer.

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Available abstract

Key concepts: Pancreatic cancer, Stromal cell, Tumor microenvironment, Cancer research, Stroma, Medicine, CXC chemokine receptors, Cancer