1990•Human HeredityRequires access
Genetic-Epidemiologic Study of Haemophilia A and B in Hungary
L. Istv aacute n, Andrew E. Czeizel, M. Ker eacute nyi, A.M. T oacute th, E Domby
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Abstract
All known surviving haemophiliacs A and B and their relatives were reexamined by laboratory and clinical methods and evaluated by a genetic-epidemiologic approach in 4 north-western countries of Hungary. The prevalence of haemophilia A and B patients born in the fifties was 2.73 and 0.25 per 10,000 persons, respectively. The reproductive fitness was found to be 0.3 in haemophilia A, and 0.8 in haemophilia B patients. The mutation rates calculated by the indirect method were 6.3 x 10(-5) for haemophilia A and 0.2 x 10(-5) for haemophilia B.