1974•Archives of NeurologyRequires access

Serotonin-Induced Muscle Weakness

Bernard M. Patten, Keminer Oliver, W. King Engel

Abstract

Infusions of serotonin into a rat nervemuscle preparation decreased the force of the evoked twitch of anterior tibial and soleus muscles. Antiserotonin drugs (cyproheptadine hydrochloride, methysergide, chlorpromazine hydrochloride) prevented the adverse effect of serotonin if they were given prior to the serotonin infusion. These experiments support the hypothesis that serotonin may play a role in some diseases of muscle.

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Key concepts: Methysergide, Cyproheptadine, Serotonin, Serotonin Antagonists, Medicine, Serotonin syndrome, Internal medicine, Endocrinology