2004•Biochemical Society TransactionsRequires access

Programmed −1 ribosomal frameshifting in the SARS coronavirus

F. Ramos, Maryté Benavides- Carrasco, Timothy C. Doyle, Ian Brierley

Abstract

Programmed -1 ribosomal frameshifting is an alternate mechanism of translation used by coronavirus to synthesize replication proteins encoded by two overlapping open reading frames. For some coronaviruses, the mRNA cis-acting stimulatory structures involved in this process have been characterized, but their precise contribution to ribosomal frameshifting is not completely understood. Recently, a novel coronavirus was identified as the causative agent of the severe acute respiratory syndrome. This review describes the mRNA motifs involved in programmed -1 ribosomal frameshifting in this virus.

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Key concepts: Translational frameshift, Coronavirus, Ribosome, Translation (biology), Virology, Biology, Open reading frame, Ribosomal RNA