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2011•Angewandte Chemie International EditionOpen access

Remarkably High Reactivity of Pd(OAc)2/Pyridine Catalysts: Nondirected CH Oxygenation of Arenes

Marion H. Emmert, Amanda K. Cook, Yushu J. Xie, Melanie S. Sanford

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Abstract

Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the CH oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2 alone.

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Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the CH oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2 alone.

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Available abstract

Less is more: The rational optimization and general applicability of the catalytic system Pd(OAc)2/pyridine is described (see scheme). The catalyst shows excellent reactivity in the CH oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)2 alone.

Key concepts: Pyridine, Reactivity (psychology), Catalysis, Chemistry, Selectivity, Oxygenation, Medicinal chemistry, Organic chemistry

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