2010•Therapeutic Drug MonitoringRequires access

Perspectives of Liquid Chromatography Coupled to Low- and High-Resolution Mass Spectrometry for Screening, Identification, and Quantification of Drugs in Clinical and Forensic Toxicology

Hans H. Maurer

Abstract

This article reviews papers on the use of liquid chromatography coupled to low- and high-resolution mass spectrometry in clinical and forensic toxicology. They cover procedures for target and for more comprehensive screening for drugs (of abuse), identification of drug metabolites, and multianalyte procedures for quantification of drugs and/or their metabolites in body samples. Besides a critical overview, perspectives are discussed.

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Key concepts: Forensic toxicology, Clinical toxicology, Chromatography, Drugs of abuse, Mass spectrometry, Chemistry, Identification (biology), Liquid chromatography–mass spectrometry