2008•PharmacologyRequires access

Influence of Phosphoserine on the Performance of Rats on the Rotarod

Ottorino Fanelli

Abstract

The anti-fatigue effect of phosphoserine, L-serine and a mixture of sodium phosphate and L-serine has been studied in rats. Phosphoserine orally administered induced a statistically significant anti-fatigue effect in rats of both sexes submitted to a training test by rotarod, with 14 sessions in 3 days. Furthermore, phosphoserine was utilized better than the mixture of sodium phosphate and L-serine, whereas L-serine alone induced no effect. Therefore the effect of phosphoserine seems to be due to the phosphoryl bond.

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Key concepts: Phosphoserine, Serine, Chemistry, Endocrinology, Internal medicine, Phosphate, Phosphorylation, Biochemistry