2014•Molecular BioSystemsRequires access
Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase
Tingting Chu, Qianqian Li, Tian Qiu, Zhanyi Sun, Zhiwen Hu, Yong‐Xiang Chen, Yufen Zhao, Yanmei Li
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Abstract
Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial 'hydrolase' I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable 'hydrolase' I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.