2002The Journal of Cell BiologyOpen access

Securin correct separation

Nicole LeBrasseur

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Abstract

![Graphic][1] Securin prevents separase from cleaving Scc1 before anaphase. Uhlmann/ElsevierThe separation of sister chromatids at anaphase cannot commence until separase cleaves the cohesin subunit Scc1. Separase is regulated by an inhibitor, securin, that seems to have

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![Graphic][1] Securin prevents separase from cleaving Scc1 before anaphase. Uhlmann/ElsevierThe separation of sister chromatids at anaphase cannot commence until separase cleaves the cohesin subunit Scc1. Separase is regulated by an inhibitor, securin, that seems to have

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Available abstract

![Graphic][1] Securin prevents separase from cleaving Scc1 before anaphase. Uhlmann/ElsevierThe separation of sister chromatids at anaphase cannot commence until separase cleaves the cohesin subunit Scc1. Separase is regulated by an inhibitor, securin, that seems to have

Key concepts: Separase, Securin, Cohesin, Anaphase, Biology, Sister chromatids, Cell biology, Chromatid

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