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1970•Hormone and Metabolic ResearchRequires access

Action of Streptozotocin on Insulin and Glucagon Responses of Rat Islets

Nikolaos Katsilambros, Yusof Rahman, M. Hinz, R. Fußgänger, K. Schröder, Karl D. Straub, E. F. Pfeiffer

Open publisher page 40 citations

Abstract

Experimental diabetes was produced in rats by i.v. streptozotocin injection (65 mg/kg). There was a significant increase in blood glucose and serum glucagon, while there was a significant decrease in serum insulin in diabetic animals as compared with controls. It is of interest that the glucagon elevation in the streptozotocin-induced diabetes in animals is of comparable magnitude to that seen in the ketoacidotic state of human diabetes.

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What this paper is about

Experimental diabetes was produced in rats by i.v. streptozotocin injection (65 mg/kg). There was a significant increase in blood glucose and serum glucagon, while there was a significant decrease in serum insulin in diabetic animals as compared with controls. It is of interest that the glucagon elevation in the streptozotocin-induced diabetes in animals is of comparable magnitude to that seen in the ketoacidotic state of human diabetes.

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Available abstract

Experimental diabetes was produced in rats by i.v. streptozotocin injection (65 mg/kg). There was a significant increase in blood glucose and serum glucagon, while there was a significant decrease in serum insulin in diabetic animals as compared with controls. It is of interest that the glucagon elevation in the streptozotocin-induced diabetes in animals is of comparable magnitude to that seen in the ketoacidotic state of human diabetes.

Key concepts: Internal medicine, Streptozotocin, Endocrinology, Glucagon, Diabetes mellitus, Insulin, Medicine, Islet

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Action of Streptozotocin on Insulin and Glucagon Responses of Rat Islets — Research Paper | ScholarLens