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(η5-Triphenylindenyl)Ru(CO)2Cl: A New Ruthenium Catalyst for the Highly Efficient Racemization of Chiral 1-Phenylethanol at Room Temperature

Xumu Zhang, Qiang Xi, Weicheng Zhang

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Abstract

A new ruthenium complex, (η5-triphenylindenyl)Ru(CO)2Cl, was synthesized and successfully applied in the racemization of (S)-1-phenylethanol at room temperature. Instead of potassium tert-butoxide, stronger bases such as sodium hydride and n-butyllithium were used to activate the precatalyst. In situ NMR experiments revealed the presence of ruthenium hydride as a key intermediate in the catalytic cycle.

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What this paper is about

A new ruthenium complex, (η5-triphenylindenyl)Ru(CO)2Cl, was synthesized and successfully applied in the racemization of (S)-1-phenylethanol at room temperature. Instead of potassium tert-butoxide, stronger bases such as sodium hydride and n-butyllithium were used to activate the precatalyst. In situ NMR experiments revealed the presence of ruthenium hydride as a key intermediate in the catalytic cycle.

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Available abstract

A new ruthenium complex, (η5-triphenylindenyl)Ru(CO)2Cl, was synthesized and successfully applied in the racemization of (S)-1-phenylethanol at room temperature. Instead of potassium tert-butoxide, stronger bases such as sodium hydride and n-butyllithium were used to activate the precatalyst. In situ NMR experiments revealed the presence of ruthenium hydride as a key intermediate in the catalytic cycle.

Key concepts: Ruthenium, Racemization, Chemistry, Catalysis, Sodium hydride, Hydride, Medicinal chemistry, Potassium

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(η5-Triphenylindenyl)Ru(CO)2Cl: A New Ruthenium Catalyst for the Highly Efficient Racemization of Chiral 1-Phenylethanol at Room Temperature — Research Paper | ScholarLens