Diarylsulfonamides as selective, non-peptidic thrombin inhibitors
Ingo R. Weber, Richard Neidlein, Wolfgang von der Saal, Frank Grams, Herbert Leinert, K. Strein, Richard A. Engh, Ralf Kucznierz
Abstract
Ingo R. Weber, Richard Neidlein, Wolfgang von der Saal, Frank Grams, Herbert Leinert, K. Strein, Richard A. Engh, Ralf Kucznierz
Abstract
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Key concepts: Thrombin, Chemistry, Discovery and development of direct thrombin inhibitors, Trypsin, Plasmin, Stereochemistry, Biochemistry, Enzyme