1954•Experimental Biology and MedicineRequires access

Liver as the Site of Synthesis of Nicotinic Acid from Tryptophane in Rats.

N. C. Ghosh, K. Chatterjee, D P Chattopadhyay, Sandip Banerjee

Abstract

1. Intraperitoneal injections of carbon tetrachloride in rats fed a dl-tryptophane supplemented nicotinic acid-deficient diet lowered urinary excretion of nicotinic acid, quinolinic acid and N-MN. 2. Liver homogenates of normal rats converted tryptophane to quinolinic acid more efficiently than that of carbon tetrachloride-treated rats. 3. It is suggested that liver is the principal site of synthesis of nicotinic acid and quinolinic acid from tryptophane.

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Key concepts: Quinolinic acid, Nicotinic agonist, Carbon tetrachloride, Nicotinic Acids, Chemistry, Tryptophan, Biochemistry, Anthranilic acid