Medizinisch interessante Metallchelate, VI Synthese eines tripodalen Triisocyanid‐Liganden und seine Reaktion mit Na[99mTcO4]

Metal Chelates of Medical Interest, VI. – Synthesis of a Tripodal Triisocyanide Ligand and its Reaction with Na[99mTcO4] The tripodal triisocyanide ligand tris[3‐(2‐isocyanophenoxy)‐ propyl]amine, TARC (6), is prepared from tris(3‐chloropropyl)‐ amine (1) and the potassium salt of 2‐nitrophenole followed by reduction of the nitro functions and conversion of the primary amines into isocyanide functions by the method of Ugi et al. The structure of the intermediate tris[3‐(2‐nitrophenoxy)‐ propyl]amine (3) has been determined by X‐ray diffraction. Tripode 6 binds 99mTc from nuclide generator‐produced Na[99mTcO4].