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Suppression of Chronic Allergic Encephalomyelitis: Relevance to Multiple Sclerosis

Cedric S. Raine, Ute Traugott, Sanford H. Stone

Abstract

The expression of chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs was suppressed with a single series of injections of myelin basic protein in incomplete Freund's adjuvant. The suppression appeared permanent, and subsequent rechallenge with central nervous system antigen failed to elicit exacerbations.

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Key concepts: Encephalomyelitis, Multiple sclerosis, Immunology, Myelin basic protein, Medicine, Myelin, Central nervous system, Adjuvant