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2011•Procedia Environmental SciencesOpen access

Schizophrenic Patients and Their Unaffected Siblings Show Similar Abnormalities in Resting-State Functional Connectivity

Meijie Liu, Lubin Wang, Hui Shen, Zhening Liu, Dewen Hu

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Abstract

Functional connectivities throughout the whole brain were examined in schizophrenic patients (Sch), their unaffected siblings (Usib) and healthy controls (HC) using resting-state functional magnetic resonance imaging. The abnormalities in functional connectivity were identified both in schizophrenic patients and in their unaffected siblings via two-sample T-test at the threshold of P<0.05 between 24 Sch and 25 HC, 25 Usib and 25 HC, respectively. From the results of the two-sample T-test, it was found that schizophrenic patients and their unaffected siblings show similar abnormalities in resting-state functional connectivity, including 97 decreased functional connectivities and 22 increased functional connectivities. The experiment results, to some extent, provided a powerful support for inheritance characteristic of schizophrenia.

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What this paper is about

Functional connectivities throughout the whole brain were examined in schizophrenic patients (Sch), their unaffected siblings (Usib) and healthy controls (HC) using resting-state functional magnetic resonance imaging. The abnormalities in functional connectivity were identified both in schizophrenic patients and in their unaffected siblings via two-sample T-test at the threshold of P<0.05 between 24 Sch and 25 HC, 25 Usib and 25 HC, respectively. From the results of the two-sample T-test, it was found that schizophrenic patients and their unaffected siblings show similar abnormalities in resting-state functional connectivity, including 97 decreased functional connectivities and 22 increased functional connectivities. The experiment results, to some extent, provided a powerful support for inheritance characteristic of schizophrenia.

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Available abstract

Functional connectivities throughout the whole brain were examined in schizophrenic patients (Sch), their unaffected siblings (Usib) and healthy controls (HC) using resting-state functional magnetic resonance imaging. The abnormalities in functional connectivity were identified both in schizophrenic patients and in their unaffected siblings via two-sample T-test at the threshold of P<0.05 between 24 Sch and 25 HC, 25 Usib and 25 HC, respectively. From the results of the two-sample T-test, it was found that schizophrenic patients and their unaffected siblings show similar abnormalities in resting-state functional connectivity, including 97 decreased functional connectivities and 22 increased functional connectivities. The experiment results, to some extent, provided a powerful support for inheritance characteristic of schizophrenia.

Key concepts: Functional connectivity, Resting state fMRI, Functional magnetic resonance imaging, Functional impairment, Schizophrenia (object-oriented programming), Psychology, Neuroscience, Audiology

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