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2011•Dementia and Geriatric Cognitive DisordersRequires access

Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson’s Disease Dementia

Victoria Larsson, Knut Engedal, Dag Aarsland, Carina Wattmo, Lennart Minthon, Elisabet Londos

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Abstract

AIM: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. METHODS: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. RESULTS: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. CONCLUSION: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.

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What this paper is about

AIM: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. METHODS: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. RESULTS: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. CONCLUSION: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.

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Available abstract

AIM: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. METHODS: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. RESULTS: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. CONCLUSION: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.

Key concepts: Dementia with Lewy bodies, Memantine, Lewy body, Dementia, Quality of life (healthcare), Parkinson's disease, Alzheimer's disease, Psychology

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Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson’s Disease Dementia — Research Paper | ScholarLens