Changes in Plasma Proteins of Mice During Rejection of Skin Homografts and Heterografts.

Mice which have received homografts and heterografts respond by increasing the level of their alpha 2 globulins. A greater increase of alpha 2 globulins is observed following the application of second set grafts, and a decrease in alpha 2 globulins can be demonstrated following excision of foreign tissue grafts. Such findings suggest that the alpha 2 globulins are altered by foreign tissue antibody formation. That such antibodies are related to the specific destruction of foreign tissue implants, however, is conjectural.