1997•Chemical and Pharmaceutical BulletinOpen access

Studies on the Constituents of Broussonetia Species. I. Two New Pyrrolidine Alkaloids, Broussonetines C and D, as .BETA.-Galactosidase and .BETA.-Mannosidase Inhibitors from Broussonetia kazinoki SIEB.

Makio Shibano, Satoshi KITAGAWA, Genjiro Kusano

Abstract

Two new pyrrolidine alkaloids called broussonetines C and D were isolated from the branch of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines C and D were formulated as (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-(10-oxo-hydroxytridecyl)pyrrolidine (1) and (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-(9-oxo-13-hydroxytridecyl)pyrrolidine (2), respectively, by spectroscopic and chemical methods. 1 and 2 showed an inhibition to β-galactosidase and β-mannosidase.

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Key concepts: Pyrrolidine, Chemistry, Broussonetia, Hydroxymethyl, Moraceae, Stereochemistry, BETA (programming language), Traditional medicine