Synthesis of N‐lactosylated thiourea and benzothiazolyl thiourea

Abstract Several N‐lactosylated aryl thioureas and benzothiazolyl thioureas have been prepared by the condensation of hepta‐O‐acetyl‐β‐D‐lactosyl isothiocyanate with aryl amines and 2‐aminobenzothiazole/substituted benzothiazoles. Hepta‐O‐acetyl‐β‐D‐lactosyl isothiocyanate was prepared by the interaction of hepta‐O‐acetyl‐α‐D‐lactosyl bromide and lead thiocyanate. The structures of these new N‐lactosides have been established on the basis of IR, NMR, and mass spectral studies. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:306–309, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20207