Hailong Ren, Chunrui Wu, Xiuxiu Ding, Xiaoge Chen, Feng Shi
Abstract
The [3 + 2] cycloaddition of arynes with 3-oxidopyridinium species is examined using the Kobayashi benzyne precursor. The reaction affords a bicyclo[3.2.1] skeleton under mild conditions. A [7 + 2] cycloaddition mode with a subsequent pyridine ring-opening event has also been observed.
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The [3 + 2] cycloaddition of arynes with 3-oxidopyridinium species is examined using the Kobayashi benzyne precursor. The reaction affords a bicyclo[3.2.1] skeleton under mild conditions. A [7 + 2] cycloaddition mode with a subsequent pyridine ring-opening event has also been observed.
Key concepts: Aryne, Cycloaddition, Chemistry, Pyridine, Ring (chemistry), Bicyclic molecule, Medicinal chemistry, Stereochemistry