2005•Antimicrobial Agents and ChemotherapyOpen access

Moxifloxacin and Azithromycin but not Amoxicillin Protect Human Respiratory Epithelial Cells against Streptococcus pneumoniae In Vitro when Administered up to 6 Hours after Challenge

Martina Ulrich, Cordula Albers, Jan-Georg Möller, Axel Dalhoff, Gisela Korfmann, Frank Künkele, Gerd K. Döring

Abstract

We determined the protective effect of moxifloxacin, azithromycin, and amoxicillin against Streptococcus pneumoniae infection of respiratory cells. Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective.

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Key concepts: Moxifloxacin, Streptococcus pneumoniae, Azithromycin, Amoxicillin, Microbiology, Antibacterial agent, In vitro, Respiratory system