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2012•Critical CareOpen access

Role of mannose-binding lectin on pneumococcal infections

Jordi Solé Violán, I García-Laorden, Felipe Rodrı́guez de Castro, Antoni Payeras, J.M. Ferrer Agüero, M. Luisa Briones, Luis Borderías, Javier Aspa, José Blanquer, Olga Rajas, Miguel Ángel García Bello, Judith Noda, Jordi Rello, C. Rodríguez Gallego

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Abstract

The role of mannose-binding lectin (MBL) deficiency (MBL2 XA/O + O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, SP-A2 and SP-D, and other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analyzed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.

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What this paper is about

The role of mannose-binding lectin (MBL) deficiency (MBL2 XA/O + O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, SP-A2 and SP-D, and other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analyzed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.

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Available abstract

The role of mannose-binding lectin (MBL) deficiency (MBL2 XA/O + O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, SP-A2 and SP-D, and other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analyzed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes.

Key concepts: Mannan-binding lectin, Collectin, Immunology, Medicine, Surfactant protein D, Lectin, Gene, Microbiology

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