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2010•The Pediatric Infectious Disease JournalRequires access

PULMONARY ASPERGILLOSIS CAUSED BY A PAN-AZOLE-RESISTANT ASPERGILLUS FUMIGATUS IN A 10-YEAR-OLD BOY

Valtyr Stefansson Thors, Marc Bierings, Willem J. G. Melchers, Paul E. Verweij, Tom F.W. Wolfs

Open publisher page 13 citations

Abstract

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

About this research paper

What this paper is about

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

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OpenAlex reports 13 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.

Key concepts: Aspergillus fumigatus, Voriconazole, Azole, Aspergillosis, Amphotericin B, Aspergillus, Hematopoietic stem cell transplantation, Medicine

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PULMONARY ASPERGILLOSIS CAUSED BY A PAN-AZOLE-RESISTANT ASPERGILLUS FUMIGATUS IN A 10-YEAR-OLD BOY — Research Paper | ScholarLens