Antipsychotic medication and marked hyperprolactinaemia: iatros or true prolactinoma?

AIM: To demonstrate that hyperprolactinaemia and/or prolactinoma occur in association with antipsychotic medication use. METHODS: Three case studies of patients with markedly elevated serum prolactin level (>132 microg/l); either antipsychotic medication induced or as a consequence of a prolactinoma. CONCLUSION: The management and investigation of children with markedly elevated serum prolactin levels remains poorly defined. In our case series, two patients were found to have prolactinomas. We suggest that paediatric patients with serum prolactin level above 50 microg/l in males and 70 microg/l in females, regardless of any antipsychotic medication use, receive magnetic resonance imaging to exclude prolactinoma.