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Central Pontine and Extrapontine Myelinolysis following Correction of Severe Hyponatremia

Ramón Peces, P Ablanedo, JoAnn Alvarez

Open publisher page 27 citations

Abstract

A chronically hyponatremic patient developed neurological features of pontine level disconnection following the raising of serum sodium. At autopsy histopathological examination confirmed the presence of myelinolysis in the central pons and similar symmetrical lesions in the thalamus. In chronic hyponatremic patients, more than the rapidity of correction, the magnitude of the osmolar change may predispose to development of these lesions.

About this research paper

What this paper is about

A chronically hyponatremic patient developed neurological features of pontine level disconnection following the raising of serum sodium. At autopsy histopathological examination confirmed the presence of myelinolysis in the central pons and similar symmetrical lesions in the thalamus. In chronic hyponatremic patients, more than the rapidity of correction, the magnitude of the osmolar change may predispose to development of these lesions.

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OpenAlex reports 27 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A chronically hyponatremic patient developed neurological features of pontine level disconnection following the raising of serum sodium. At autopsy histopathological examination confirmed the presence of myelinolysis in the central pons and similar symmetrical lesions in the thalamus. In chronic hyponatremic patients, more than the rapidity of correction, the magnitude of the osmolar change may predispose to development of these lesions.

Key concepts: Central pontine myelinolysis, Hyponatremia, Medicine, Autopsy, Pons, Disconnection, Pathology, Internal medicine

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