2010•The Journal of Organic ChemistryRequires access
Asymmetric Direct Vinylogous Aldol Reaction of Unactivated γ-Butenolide to Aldehydes
Yang Yang, Ke Zheng, Jiannan Zhao, Jian Shi, Lili Lin, Xiaohua Liu, Xiaoming Feng
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Abstract
The asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide with aldehydes has been developed, giving the corresponding 5-(1'-hydroxy)butenolide derivatives in high yields (up to 93%) and enantioselectivities (up to 83% ee) under mild conditions.