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Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to Barbiturates

Geoffrey P. Redmond, Gerald Leonard Cohen

Abstract

Mice were injected twice a day for 4 days with saline or phenobarbital or ethanol. Treatment with phenobarbital, but not ethanol, increased the amount of liver acetaldehyde dehydrogenase activity. More rapid removal of acetaldehyde, which is a toxic metabolic intermediate of ethanol, may contribute to the alcohol tolerance exhibited by persons who use barbiturates regularly.

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Key concepts: Acetaldehyde, Ethanol, Phenobarbital, Alcohol dehydrogenase, Chemistry, Ethanol metabolism, Aldehyde dehydrogenase, Pharmacology