1984•Antimicrobial Agents and ChemotherapyOpen access

Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin

S C Aronoff, M R Jacobs, S Johenning, Shigeru Yamabe

Abstract

YTR 830, a new beta-lactamase inhibitor, was compared with clavulanic acid and sulbactam against aminopenicillin-resistant clinical isolates. At a concentration of 8 micrograms/ml, YTR 830 was as effective as clavulanate or sulbactam in reducing the aminopenicillin MICs. Combined with amoxicillin, YTR 830 is a potentially useful agent for therapy of many bacterial infections.

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Key concepts: Sulbactam, Beta-Lactamase Inhibitors, Clavulanic acid, Ampicillin, Amoxicillin, Beta-lactamase, Microbiology, Medicine