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2009•International Archives of Allergy and Applied ImmunologyRequires access

Vernal Keratoconjunctivitis: The Significance of Immunoglobulin E Levels in Tears and Serum

Zemira Samra, Aron Zavaro, Y.R. Barishak, D Sompolinsky

Open publisher page 15 citations

Abstract

Vernal keratoconjunctivitis (VC) is an inflammatory disorder of the outer eye, probably of allergic etiology. The present study was performed on patients with a typical clinical appearance of VC and examined periodically for serum and tear IgE and albumin (HSA). The geometric mean of serum and tear IgE was 219 and 18 IU/ml, respectively, for the patients, but about 100 and less than 1 IU/ml for serum and tears of healthy controls and of parents of VC patients. A positive correlation between variations in tear IgE and tear HSA was observed, indicating that tear IgE levels have a significant influence on the intensity of the inflammatory process.

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What this paper is about

Vernal keratoconjunctivitis (VC) is an inflammatory disorder of the outer eye, probably of allergic etiology. The present study was performed on patients with a typical clinical appearance of VC and examined periodically for serum and tear IgE and albumin (HSA). The geometric mean of serum and tear IgE was 219 and 18 IU/ml, respectively, for the patients, but about 100 and less than 1 IU/ml for serum and tears of healthy controls and of parents of VC patients. A positive correlation between variations in tear IgE and tear HSA was observed, indicating that tear IgE levels have a significant influence on the intensity of the inflammatory process.

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OpenAlex reports 15 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Vernal keratoconjunctivitis (VC) is an inflammatory disorder of the outer eye, probably of allergic etiology. The present study was performed on patients with a typical clinical appearance of VC and examined periodically for serum and tear IgE and albumin (HSA). The geometric mean of serum and tear IgE was 219 and 18 IU/ml, respectively, for the patients, but about 100 and less than 1 IU/ml for serum and tears of healthy controls and of parents of VC patients. A positive correlation between variations in tear IgE and tear HSA was observed, indicating that tear IgE levels have a significant influence on the intensity of the inflammatory process.

Key concepts: Vernal keratoconjunctivitis, Immunoglobulin E, Tears, Medicine, Immunology, Etiology, Keratoconjunctivitis, Antibody

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