Various doses of cisplatin (DDP) combined with multi-drug chemotherapy for advanced malignant solid tumor

Two hundred and thirty-six patinets with various advanced malignant solid tumors treated by combined chemotherapy with routine doses of cisplatin (DDP) from 1980 to 1986 are presented. According to different doses of cisplatin everyday, the patients were divided into 4 groups: (1) 20 mg/day×4–5, 80 cases; (2) 30 mg/day× 3–5, 91 cases; (3) 40 mg/day 3–4, 37 cases; (4) 50 mg/day×2–3, 28 cases. Each group was repeated for 3 weeks. The effect and toxicity were analysed and compared with 22 cases treated by single DDP in 1975. The response (CR+PR) rate was 39.2% in 194 evaluated patients. The response rate was similar in group 20 mg and single DDP (29.2% and 27.3%). The response rate was lower than that of group 30 mg, 40 mg, and 50 mg 43.4% and 50%) ( P <0.05). The remissions in various groups were not significantly different. The toxicity of combined chemotherapy was not severe. 91.1% of patients had nausea and vomiting. There was no statistical difference in the various groups. Bone marrow suppresion was less in single DDP group than that of combined chemotherapy group (P<0.05), DDP 30–50 mg 1/d×5–3 was better than HD-DDP in some patients.