2006•Bioscience Biotechnology and BiochemistryRequires access

Enhancement of Stress Tolerance inSaccharomyces cerevisiaeby Overexpression of Ubiquitin Ligase Rsp5 and Ubiquitin-Conjugating Enzymes

Hiroyuki Hiraishi, Mai Mochizuki, Hiroshi Takagi

Abstract

Yeast Saccharomyces cerevisiae cells overexpressing essential ubiquitin ligase Rsp5 or ubiquitin-conjugating enzymes (Ubc1-Ubc13) showed tolerance to various stresses. Co-overexpression of Rsp5 and Ubc1, Ubc2, Ubc3, Ubc5, Ubc6, Ubc9, Ubc10, Ubc11, Ubc12, or Ubc13 further enhanced stress tolerance. These results suggest that overexpression of ubiquitin-related enzymes might be a useful method for breeding novel stress-resistant strains.

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Key concepts: Ubiquitin ligase, Ubiquitin-conjugating enzyme, Saccharomyces cerevisiae, DNA ligase, Ubiquitin, Enzyme, Yeast, Biochemistry