Reconstruction of ossicles by tissue glue (histoacryl) in dogs

Abstract While performing tympanoplasties, in 30–40 percent of the cases, the ossicular assembly does not heal as positioned, or, if healed, it will break down later, and the grafted tympanic membrane may separate from the ossicular chain. Histoacryl (2‐Cyano‐Butyl‐Acrylate) was used in 20 middle ears of dogs to determine how this tissue adhesive would react. It was hoped that it might be found safe and useful for use in the human. Surgically on all dogs glue was used in the experimental ear; in the opposite or control ear, the identical operation was performed without glue. The histological sections were obtained 10 weeks following surgery. Structures united with tissue adhesive were: 1. fascia to tympanic membrane; 2. cartilage to footplate; 3. bone to footplate; and 4. incus interposition between malleus and stapes. Examination of 12 histological slides reveal it is clearly demonstrable that Histoacryl is harmless to middle and inner ear structures, is absorbed within a short period of time, and creates stable tissue union. It is believed proven safe for use in human middle ears.