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1984•The Journal of DermatologyRequires access

EFFECTS OF MOUSE AND HUMAN EPIDERMAL GROWTH FACTOR ON THE OUTGROWING EPIDERMIS OF PIG AND HUMAN SKIN EXPLANTS

Takashi Aoyagi, Naoko Kato, Hideko Suya, Yusho Miura, Tetsunori Yoshida, Takehiko Ohura

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Abstract

ABSTRACT The effects of mouse and human epidermal growth factors (mEGF and hEGF) on the outgrowing epidermis of pig and human skin explants were studied. Both mEGF and hEGF significantly stimulated the rate of pig and human epidermal outgrowth at 0.01–0.05 µg/ml. mEGF also stimulated mitosis of pig outgrowing epidermis. The stimulatory effect of mEGF on the rate of pig epidermal outgrowth and mitosis of pig outgrowing epidermis was potentiated by fetal calf serum. These results indicate that EGF may have a possibile clinical application in epidermal wound healing.

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ABSTRACT The effects of mouse and human epidermal growth factors (mEGF and hEGF) on the outgrowing epidermis of pig and human skin explants were studied. Both mEGF and hEGF significantly stimulated the rate of pig and human epidermal outgrowth at 0.01–0.05 µg/ml. mEGF also stimulated mitosis of pig outgrowing epidermis. The stimulatory effect of mEGF on the rate of pig epidermal outgrowth and mitosis of pig outgrowing epidermis was potentiated by fetal calf serum. These results indicate that EGF may have a possibile clinical application in epidermal wound healing.

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Available abstract

ABSTRACT The effects of mouse and human epidermal growth factors (mEGF and hEGF) on the outgrowing epidermis of pig and human skin explants were studied. Both mEGF and hEGF significantly stimulated the rate of pig and human epidermal outgrowth at 0.01–0.05 µg/ml. mEGF also stimulated mitosis of pig outgrowing epidermis. The stimulatory effect of mEGF on the rate of pig epidermal outgrowth and mitosis of pig outgrowing epidermis was potentiated by fetal calf serum. These results indicate that EGF may have a possibile clinical application in epidermal wound healing.

Key concepts: Epidermis (zoology), Pig skin, Mitosis, Epidermal growth factor, Explant culture, Biology, Embryo, Anatomy

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EFFECTS OF MOUSE AND HUMAN EPIDERMAL GROWTH FACTOR ON THE OUTGROWING EPIDERMIS OF PIG AND HUMAN SKIN EXPLANTS — Research Paper | ScholarLens