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Alkalikationen‐Spezifität und Träger‐Eigenschaften der Antibiotica Nigericin und Monensin

Werner K. Lutz, H.‐K. Wipf, W. Simon

Abstract

Abstract It is shown by means of IR. spectroscopic methods that nigericin and monensin have a cyclic conformation similar to that of their silver salts. Complex formation constants with sodium and potassium ions follow the selectivity order determined by EMF. measurements on liquid membranes: nigericin: K+ > Rb+ > Na+ > Cs+ > Li+; monensin: Na+ > K+ > Li+ > Rb+ > Cs+. Transport experiments show that nigericin and monensin facilitate the diffusion of potassiumions across model membranes, although in electrolytic transport experiments the permeability is not affected.

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Available abstract

Key concepts: Nigericin, Monensin, Chemistry, Membrane, Ionophore, Potassium, Sodium, Inorganic chemistry