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1998•Journal of Cardiovascular ElectrophysiologyRequires access

Cisapride‐Induced Torsades de Pointes

João V. Vítola, Jasminka Vukanovic, Dan M. Roden

Open publisher page 84 citations

Abstract

Two cases of torsades de pointes associated with cisapride are presented, both in association with concomitant drug therapy that inhibits cisapride biotransformation. In one case, plasma cisapride was elevated days after the event, strongly supporting a role for accumulation of the drug in causing the arrhythmia. It is emphasized that these adverse drug reactions are not idiosyncratic, but rather are predictable based on an understanding of the underlying mechanisms.

About this research paper

What this paper is about

Two cases of torsades de pointes associated with cisapride are presented, both in association with concomitant drug therapy that inhibits cisapride biotransformation. In one case, plasma cisapride was elevated days after the event, strongly supporting a role for accumulation of the drug in causing the arrhythmia. It is emphasized that these adverse drug reactions are not idiosyncratic, but rather are predictable based on an understanding of the underlying mechanisms.

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OpenAlex reports 84 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Two cases of torsades de pointes associated with cisapride are presented, both in association with concomitant drug therapy that inhibits cisapride biotransformation. In one case, plasma cisapride was elevated days after the event, strongly supporting a role for accumulation of the drug in causing the arrhythmia. It is emphasized that these adverse drug reactions are not idiosyncratic, but rather are predictable based on an understanding of the underlying mechanisms.

Key concepts: Cisapride, Torsades de pointes, Medicine, QT interval, Drug, Concomitant, Pharmacology, Adverse effect

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