The rate of condensation of some tripeptide methyl esters in solution

Abstract The condensation rate of a few tripeptide methyl esters in methanol has been studied at 65° C. The peptide esters with a glycyl residue at both ends have been found to be equally reactive, regardless of the nature of the amino acid residue in the middle. A side chain situated on one of the terminal amino acid residues decreases the reaction rate (table I).