1977•The Journal of AntibioticsOpen access

Uptake of 2'-amino-2'-deoxyguanosine by Escherichia coli and its competition by guanosine.

Toshihide Nakanishi, Fusao Tomita, Akira Furuya

Abstract

The antibacterial activity of a new nucleoside antibiotic, 2'-amino-2'-deoxyguanosine (2AG), is reversed by guanosine and other purine nucleosides. 2AG is apparently taken up by E. coli by a mechanism different from that of guanosine; guanosine inhibits this uptake non-competitively. Insensitive E. coli strains and the resistant mutant obtained from the sensitive strain also took up 2AG.

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Key concepts: Guanosine, Deoxyguanosine, Nucleoside, Chemistry, Purine, Escherichia coli, Mutant, Biochemistry