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Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

Teruyo Sakakura, Yasuaki Nishizuka, Clyde J. Dawe

Abstract

Isografts of heterotypic recombinants of embryonic mammary epithelium with salivary mesenchyme undergo development morphogenetically resembling that of salivary gland. However, cytodifferentiation of the epithelium is like that of mammary gland. In lactating hosts these isografts respond to endogenous hormonal stimulation and synthesize a milk protein, alpha-lactalbumin.

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Key concepts: Mesenchyme, Epithelium, Morphogenesis, Mammary gland, Biology, Salivary gland, Cell biology, Endocrinology