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2015•Clinical Interventions in AgingOpen access

Personalized therapeutics of α1-blockers in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia

Quan Zhou, Ling-ling Zhu, Zhijun Feng

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Abstract

Personalized therapeutics of α1-blockers in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia Ling-ling Zhu,1 Zhi-jun Feng,2 Quan Zhou3 1Geriatric VIP Ward, Division of Nursing, 2Department of Urology Surgery, 3Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China We read with great interest the multicenter, prospective, comparative cohort study by Zhang et al1 who suggested that patients with uncontrolled or untreated hypertension and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS) should be warned about a decrease in blood pressure on initiation of alfuzosin 10 mg therapy alone or concomitantly with antihypertensive medication. Here we discuss and share our perspectives on this issue.

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Personalized therapeutics of α1-blockers in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia Ling-ling Zhu,1 Zhi-jun Feng,2 Quan Zhou3 1Geriatric VIP Ward, Division of Nursing, 2Department of Urology Surgery, 3Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China We read with great interest the multicenter, prospective, comparative cohort study by Zhang et al1 who suggested that patients with uncontrolled or untreated hypertension and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS) should be warned about a decrease in blood pressure on initiation of alfuzosin 10 mg therapy alone or concomitantly with antihypertensive medication. Here we discuss and share our perspectives on this issue.

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Available abstract

Personalized therapeutics of α1-blockers in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia Ling-ling Zhu,1 Zhi-jun Feng,2 Quan Zhou3 1Geriatric VIP Ward, Division of Nursing, 2Department of Urology Surgery, 3Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China We read with great interest the multicenter, prospective, comparative cohort study by Zhang et al1 who suggested that patients with uncontrolled or untreated hypertension and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS) should be warned about a decrease in blood pressure on initiation of alfuzosin 10 mg therapy alone or concomitantly with antihypertensive medication. Here we discuss and share our perspectives on this issue.

Key concepts: Medicine, Lower urinary tract symptoms, Alfuzosin, Hyperplasia, Urology, Urinary system, Pharmacy, Prospective cohort study

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