Thyroid and Aging or the Aging Thyroid? An Evidence-Based Analysis of the Literature
Naveen Aggarwal, Salman Razvi
Abstract
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Naveen Aggarwal, Salman Razvi
Abstract
Open-access reader
Thyroid hormone production, metabolism, and action change with aging. The reference ranges for serum thyrotropin and thyroid hormones are derived mainly from younger populations. Thus, the prevalence of subclinical thyroid dysfunction is increased greatly in the elderly. However, it is unclear whether mild thyroid dysfunction in the elderly is associated with adverse outcomes. In this review, we discuss current evidence-based literature on thyroid function in the elderly and whether subclinical thyroid dysfunction in the elderly should be treated.
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Thyroid hormone production, metabolism, and action change with aging. The reference ranges for serum thyrotropin and thyroid hormones are derived mainly from younger populations. Thus, the prevalence of subclinical thyroid dysfunction is increased greatly in the elderly. However, it is unclear whether mild thyroid dysfunction in the elderly is associated with adverse outcomes. In this review, we discuss current evidence-based literature on thyroid function in the elderly and whether subclinical thyroid dysfunction in the elderly should be treated.
Key concepts: Subclinical infection, Medicine, Thyroid, Thyroid dysfunction, Hormone, Thyroid function, Healthy aging, Internal medicine