1993•Behavioural PharmacologyRequires access

Chronic nicotine ingestion improves radial arm maze performance in rats

S. Poincheval-Fuhrman, Susan J. Sara

Abstract

Effects of chronic nicotine treatment on spatial memory were studied in rats. After 3 weeks of administration of 2.5mg/kg/day in drinking water, the rats were submitted to a spatial learning task in an eight-arm radial maze, during which time the treatment was maintained. Chronic nicotine treatment improved daily spatial memory performance after the animals reached an asymptotic level. Nicotine-treated animals showed significantly better performance than control animals regarding the first error and the total correct path choices.

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Key concepts: Radial arm maze, Nicotine, Medicine, Ingestion, Anesthesia, Internal medicine, Working memory, Cognition